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| Details About Artesunate |
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Product Name: Product Origin: Therapeutic Use: Specifications: |
Artesunate Artemisia Annua L. Anti - Malaria Min.98.5% |
| Description | ||
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Artemisinin, isolated from Chinese-Vietnamese plant Artemisia annua L.,
locally called "qing hao", is a new class anti-malarial drugs. It is a
white crystalline powder with a bitter taste; practically insoluble in
water, soluble in chloroform, acetone, and alcohols. Its chemical
designation is (3R,5aS,6R,8aS,9R,12S,12aR)- octahydro
-3,6,9-trimethyl-3,12-epoxy- 12H-pyrano[4.3-j]-1,2-benzodioxepin-10
(3H)-one. Malaria is one of leading re-emerging infectious disease due
to murative malarial parasite developed resistance to chloroquine.
Sulfadoxine-pyrimethamine is an alternative can be used in the treatment
of the disease resistant to chloroquine, but resistance to
sulfadoxine-pyrimethamine has been reported also in some areas.
Artemisinin is an alternative used in areas where the disease has become
highly resistant to sulfadoxine-pyrimethamine. Dihydroartemisinin, its
methyl ether (artemether), its ehyl ether (its (arteether) and its
hemisuccinate ester (artesunate) are known as more effective than its
parent material - artemisinin. Artemisinin is a peroxide-bridged
sesquiterpene lactone compound which has no N atom, unlike quinine class
anti-malarial drugs. The characteristic peroxide lactone structure is
indispensable for anti-malarial activity. The term of artemotil refers
to the pure beta-epimer of arteether
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| Chemical Formula | ||
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Molecular Formula C15H22O5
Molecular Weight 282.34
CAS Number 88495-63-0
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| Therapeutic Use | ||
| Artesunate is synthetised by reacting DHA and succinic acid anhydride in alkaline medium. This type of reation invariably yields an ester linkage in alpha configuration. | ||
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