Alchem International Manufacturer & Exporter of Coenzyme Q-10(CO-Q 10) Enzyme Q10 Ubidecarenone India

Coenzyme Q10 (CoQ 10) or ubiquinone is essentially a vitamin or vitamin-like substance. Disagreements on nomenclature notwithstanding, vitamins are defined as organic compounds essential in minute amounts for normal body function acting as coenzymes or precursors to coenzymes Coenzyme Q10 is made in the body and found in almost all cells, but levels decrease as we age. It's also found in most foods, though in tiny amounts. That's why some experts advise those older than age 40 to take coenzyme Q10 supplements.

Additional benefits of the CoQ10 supplementation include : reducing the blood pressure, controlling abnormal heart rhythms, preventing atherosclerosis in the arteries and alleviating congestive heart failure (CHF) . Studies have shown that supplementation of CoQ10 improves conditions of 91% of heart attack patients within 30 days. 9, 10,

In addition, CoQ10 levels in the body directly affect our immune system. Studies have shown that persons infected with HIV and have low CoenzymeQ10 levels in their body, progress more rapidly to full-blown Acquired Immune Deficiency Syndrome (AIDS) than persons with optimal levels. 6

CoQ10 helps slow the brain aging process and aids in preventing neuron damage that leads to Alzheimer's disease. Reversal of this mental deterioration through supplementation of CoQ10 has been documented in several studies. In addition studies have shown a high dosage of CoQ10 can help treat Parkinson disease. 7, 8

Does Coenzyme Q10 have any side effects?
No serious side effects have been reported from the use of CoQ10.Some patients that used CoQ10 have experienced mild insomnia, elevated levels of liver enzymes, rashes, nausea and upper abdominal pain.

University of Maryland studied the various drugs which deplete CoQ10.These can be seen in the Table 1.

DRUGS THAT DEPLETE COENZYME Q10

Cholesterol-Lowering	Cardiovascular	Antidepressant
Medications	Medications	Medications
Fibric Acid Derivatives	Alpha2-Adrenergic Agonists	Tricyclic Antidepressants
Gemfibrozil	Clonidine	Amitriptyline
HMG-CoA Reductase Inhibitors (Statins)	Beta-Blockers	Amoxapine
Atorvastatin	Acebutolol	Clomipramine
Cerivastatin	Atenolol	Desipramine
Fluvastatin	Betaxolol	Doxepin
Lovastatin	Bisoprolol	Imipramine
Pravastatin	Carteolol	Nortriptyline
Simvastatin	Esmolol	Protriptyline
Antidiabetic Medications	Labetalol	Trimipramine
Sulfonylureas	Levobetaxolol	Diuretics
Acetohexamide	Pindolol	Thiazide Diuretics
Chlorpropamide	Propranolol	Psychotherapeutic
Glyburide	Sotalol	Medications
Tolazamide	Timolol	Phenothiazine Derivatives
Tolbutamide	Vasodilators	Thioxanthene Derivatives

1. Kent , S., "The multiple health benefits of coenzyme Q10," Life Extension, 2(2), 1996.

2. Sinatra S., The Coenzyme Q10 Phenomenon , New Canaan , CT : Keats Publishing, Inc., 1998,pp.127-129.

3. Ames , B., et al., " Oxidants, antioxidants, and the degenerative diseases of aging," Proceedings of the
National Academy of Sciences, USA, 90:7915-7922, 1993.

4. Folkers K,Langsjoen P, Willis R, Richardson P, Xia LJ, Ye CO, Tamagawa H. Lovastatin decreases coenzyme
Q10 levels in humans. Proc natl Acad Sci USA 1990 Nov;87(22):8931-4

5. De Pinieux G, Chariot p, Ammi-Said M, Louarn F, Lejonc JL,Astier A, Jacotot B, Gherardi R. Lipid lowering drugs and mitochondrial function:effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996 Sep;42(3):333-7

6. Folkers, K., et al., "Biochemical deficiencies of Coenzyme Q10 in HIV-infection and exploratory treatment," Biochemical and Biophysical Research Communications, 153(2):888-896, 1988.

7. "Coenzyme Q10: It's in your thoughts," Life Extension, 5(1):17-18, 1999.

8. "How CoQ10 protects brain cells," Life Extension, 7(10), 2001.

9. Mortensen, S. A., et al., "Long term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure," Drugs Exp Clin Res, 11(8):581-593, 1985.

10. Bitomsky, M., "Making old hearts young again," Life Extension, 5(1):12-15, 1999.

11. In-Tele-Health © 2002 (from Hyperhealth Pro CD-ROM)

12. Sinatra,Stephen, T. 2005. The Sinatra Solution , New Jersey ,Basic Health Publications

13. Bargossi AM,Battino M, gaddi A, Fiorella PL, Grossi G, Barozzi G, Di Giulio R,Descovich G, Sassi S, Genova ML, et al. Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors.Int J Clin Lab Res 1994;24(3):171-6

14. Silver MA, Langsjoen PH, Szabo S, Patil H, and Zelinger A. Statin Cardiomyopathy? A Potential Role for Coenzyme Q10 Therapy for Statin-Induced Changes in Diastolic LV Performance.

15. Palomaki A, Malminiemi K, Metsa-Ketela T. Enhanced oxidizability of ubiquinol and alpha-tocopherol during lovastatin treatment.FEBS Lett 1997 Jun 30;410(2-3):254-258

16. CoQ10 product earns orphan drug status[News and Treands]. Health Supplement Retailer.Accessed online May 19,2005,at: http://www.hsrmagazine.com/articles/0a1news.html.