UPAC name: [7(S)-(1a , -2§, 4§,5a , 7§)]-9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl -3-oxa-9-azoniatricyclo [3.3.1.0 2,4] nonane bromide.

Assay (argentometric): Not less than 98,0% and not more than 101,0% calculated with reference to the dried substance.

Product Origins: Hyoscine-N-Butylbromide is a derivative of Hyoscine which is extracted from the leaves of the Duboisia tree found mainly in Australia. This form of hyoscine is known as an antispasmodic agent and is used extensively in the treatment of a various bowel conditions.

Pharmacological Activities: Antimuscarinic drug. Hyoscine N-Butylbromide exhibits mild anticholinergic and spasmolytic atropine-like actions and possesses marked ganglionic blocking and curariform properties. Hyoscine N-Butylbromide is devoid of central nervous actions. Reduces peristalsis without loss of tone in peptic ulcer therapy; reduces spasm in gastrointestinal, biliary, and renal conditions.

Therapeutical Applications: The most frequent use for Hyoscine N-Butylbromide is in preparations which act to relax the smooth muscle of the gastrointestinal, bilary and urinary tracts. Hyoscine N-Butylbromide is also used in the treatment of obstructed bowel where surgery is not considered an option, for the relief of acute genitourinary or gastrointestinal spasm and to produce smooth muscle relaxation prior to radiological procedures. Also used to counteract the symptoms of motion sickness.

Therapeutical Category: Antispasmodic

Synonyms: (1S, 3S, 5R, 6R, 7S, 8R)-6, 7-epoxy-8-butyl-3-[(S)-tropoyloxy] tropanuium bromide. Scopolamine-N-Butylbromide. N-Butyl Scopolammonium Bromide.