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Details About Scopolia Extract    

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Scopolia Extract

Scopola Carniolica

Gastrointestinal disorders/Releives spasmodic discomfort

>0.90% alkaloids as hyoscyamine

 
Description

The genus Scopola is a connecting link between Atropa and Hyoscyamus, its leaf, flower and rhizome resembling the former, and the fruit the latter. The Japanese Scopola japonica is so closely allied that it is doubtful if it can be regarded as a distinct species.

 

S. Carniolica grows in damp, stony places in hilly districts and resembles belladonna both in appearance and characteristics. It only grows to the height of 1 foot, and has thin leaves, its fruit being a transversely dehiscent capsule.

 

The rhizome is horizontal, curved, almost cylindrical, and somewhat flattened vertically. It is usually found in pieces from 2 1/2 to 7 1/2 cm. long and 0.8 to 1.6 cm. broad, often split before drying. The upper surface is marked with closely-set, large, cup-shaped stem-scars, and the colour varies from yellowish-brown to dark, brownish-grey; the fracture is short and sharp, showing a yellowish-white bark, its corky layer dark brown, or pale brown, the central pith being rather horny. It has scarcely any odour, and the taste is sweetish at first, but afterwards bitter and strongly acrid. The Japanese rhizome is larger, with circular scars, not whitish when broken, and having a slightly mousy, narcotic odour, and practically no bitterness in taste.

The bark of S. Carniolica is less thick than in belladonna and the starch grains smaller.

Scopolia is but little used in Britain, but has been used in America for many years in the manufacture of belladonna plasters.

 

The alkaloidal constituents are similar to those of Belladonna Root, hyoscine (scopolamine), however, predominating. Inactive scopolamine, also known as atroscine, is present, melting at 82 degrees C. (179.6 degrees F.) and yielding by hydrolysis tropic acid and scopoline. The result of an assay of many tons of the root of Atropa Belladonna and of the rhizome of Scopolia, each of the best qualities to be found in the American market, showed that while belladonna yielded on an average 0.50 per cent of alkaloid, Scopolia yielded 0.58 per cent.

 

The root of S. Carniolica is official in the United States Pharmacopaeia for the production of an extract and fluid extract. It should contain not less than 0.5 per cent of alkaloids.

 

Scopolamine hydrobromide is recognized in the United States Pharmacopoeia.

 

Scopolamine or hyoscine must be preserved in well-closed containers, protected from light. When pure, it forms a syrupy liquid. Great care must be used in tasting it, and then only in dilute solutions. When dried at 100 degrees C. (212 degrees F.) it loses about 12 per cent of its weight. It is the same substance as Hyoscinae Hydrobromicum. Atroscine is an optically inert isomer of scopolamin and Euscopol is an optically inactive scopolaminum hydrobromicum.

Chemical Formula
 
Therapeutic Use