The extract is derived form the plant of Andrographis paniculata belonging to family Acanthaceae. This ancient Indian medicinal herb known as Kalmegh is historically been used as a Hepatoprotective and for common cold. It is used as a bitter ingredient in the Indian indigenous system of medicine. Traditionally the decoction of Andrographis rootstalks and leaves is commonly used as a bitter tonic, alterative, anthelmintic and antiperiodic, and is useful in intermittent fevers. The major phytoconstituent is Andrographolides.

The most common therapeutic potential of Andrographis paniculata is its liver protective property. The clinical and preclinical studies demonstrates its liver protective effects by enhancing activity of antioxidant enzymes along with the level of glutathione and decreasing the activity of lipid peroxidase which leads to generation of free radicals damaging the liver cells thus exerting a Hepatoprotective activity.

Andrographolides present in Andrographis paniculata are observed to be potential enhancers of immune system functions such as production of white blood cells which are the defense cells of our body, release of an antiviral factor called interferon, and also activity of the lymphatic system which is the seat of our defense system. Andrographis paniculata extracts are cytotoxic (cell-killing) against cancer cells. This cancer cell-killing ability was demonstrated against human epidermoid carcinoma of the skin lining of the nasopharynx and against lymphocytic leukemia cells involved in leukemia. It was also discovered during this study that the andrographolide present in Andrographis paniculata was found to have the cancer cell-killing potential. Scientific studies have also reported its use as Immunostimulant, anticancer, anti-inflammatory, contraceptive, biliary stimulator, tranquilizer and more