Sennosides (USP)

Alchem International with 75 years of experience in the phytochemical space has been diligently providing plant derived ingredients, active pharmaceutical ingredients and bulk drugs to all international significant geographies.

The success of the company's operations lie in its proprietary manufacturing processes, intensive research, willingness to combat new challenges, mesh with evolving technologies ,focussed expansion and credible response to international validations and inspections.

The production sites are US FDA approved and WHO and EU GMP certified. The company has filed ASMF/DMFs in over 20 countries worldwide. Value additions through bio-technology, semi-synthesis and foot prints in the formulation space have happened in planned progression. Alchem's interest in skin care is a logical part of this dimensional growth.

Sheer Quality drives Alchem’s operations

Through perfect blend of science and nature, dedicated research, selection of finest botanical herbal extracts and focused technology, Alchem has successfully extracted the potent active molecules in the plant and offers it for pharmaceutical use to help various companies spread wellness.

"For pharmaceutical use, Alchem offers Sennoside with all its inherent benefits"

Senna glycosides or sennosides are a number of anthraquinone derivatives useful as a laxative. They are dimeric glycosides named after their abundant occurrence in plants of the genus Senna (Cassia acutifolia Delile) or Tinnevelly senna (Cassia angustifolia Vahl). Senna contains mainly two anthraquinone glycosides such as sennoside A and sennoside B and small quantities of other anthraquinones such as sennosides C and D, rhein 8-glucoside, rhein-8-diglucoside, aloe-emodin, 8-glucoside, anthrone diglucoside and rhein. It also consists of two naphthalene glycosides namely Tinnevellin glycoside and 6-hydroxy musizin Glycoside.

Senna is known for its purgative action. The phytoconstituents principally responsible for its characteristic action is sennoside A and sennoside B. Sennoside A and B together are responsible for up to 40 – 60% activity of crude senna. These glycosides increase secretion of gastric fluids and affect colonic motility and hence, facilitate colonic transit. These phytocontituents remain unabsorbed in the upper intestinal tract. They are activated by large intestine bacteria into the active derivatives (rhein-anthrone).

Sennosides are used for the short term treatment of symptomatic constipation. It may also be used to aid in the evacuation of the bowel prior to surgery or invasive rectal or colonic examinations.

The product addresses broad spectrum physiological concerns and has the band width and capabilities to meet expectations. Regular use should exhibit demonstrable results to inhibit various health related issues.

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