Colchicine EP/USP (ANSM-ASMF No.-2014-098 & USDMF 22564)

Alchem International with 75 years of experience in the phytochemical space has been diligently providing plant derived ingredients, active pharmaceutical ingredients and bulk drugs to all international significant geographies.

The success of the company's operations lie in its proprietary manufacturing processes, intensive research, willingness to combat new challenges, mesh with evolving technologies ,focussed expansion and credible response to international validations and inspections.

The production sites are US FDA approved and WHO and EU GMP certified. The company has filed ASMF/DMFs in over 20 countries worldwide. Value additions through bio-technology, semi-synthesis and foot prints in the formulation space have happened in planned progression. Alchem's interest in skin care is a logical part of this dimensional growth.

Sheer Quality drives Alchem’s operations

Through perfect blend of science and nature, dedicated research, selection of finest botanical herbal extracts and focused technology, Alchem has successfully extracted the potent active molecules in the plant and offers it for pharmaceutical use to help various companies spread wellness.

Colchicine
"For pharmaceutical use, Alchem offers Colchicine with all its inherent benefits"

Colchicine is an alkaloid prepared from the dried corns and seeds of Colchicum autumnale, the autumn crocus or meadow saffron. The most common use of colchicine is as prophylaxis to prevent attacks of gout or pseudogout. These are types of arthritis caused by a buildup of crystals in the joints. Blood cells travel to these areas of inflammation causing pain and swelling. Colchicine prevents white blood cells from travelling into these areas, and therefore helps to reduce pain and tenderness.

Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, and therefore colchicine effectively functions as a "mitotic poison" or "spindle poison". Colchicine's pain-relieving and anti-inflammatory effects for gout are linked to its ability to bind with tubulin. Colchicine also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. Colchicine is usually effective in relieving a gout attack within 12 to 24 hours. Low doses of colchicine are effective in preventing or reducing the severity of future gout attacks.

In addition to gout, Colchicine is used in certain patients with medical conditions such as Amyloidosis, Behcet's disease, dermatitis herpetiformis, familial Mediterranean fever, Paget's disease, Pericarditis, Pseudogout, biliary and hepatic cirrhosis.

The product addresses broad spectrum physiological concerns and has the band width and capabilities to meet expectations. Regular use should exhibit demonstrable results to inhibit various health related issues.

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