Hyoscine Butylbromide IP/EP (CEP 2017-085)

Alchem International with 75 years of experience in the phytochemical space has been diligently providing plant derived ingredients, active pharmaceutical ingredients and bulk drugs to all international significant geographies.

The success of the company's operations lie in its proprietary manufacturing processes, intensive research, willingness to combat new challenges, mesh with evolving technologies ,focussed expansion and credible response to international validations and inspections.

The production sites are US FDA approved and WHO and EU GMP certified. The company has filed ASMF/DMFs in over 20 countries worldwide. Value additions through bio-technology, semi-synthesis and foot prints in the formulation space have happened in planned progression. Alchem's interest in skin care is a logical part of this dimensional growth.

Sheer Quality drives Alchem’s operations

Through perfect blend of science and nature, dedicated research, selection of finest botanical herbal extracts and focused technology, Alchem has successfully extracted the potent active molecules in the plant and offers it for pharmaceutical use to help various companies spread wellness.

Hyoscine Butylbromide
"For cosmetic use, Alchem offers Glabridin with all its inherent benefits"

Scopolamine or hyoscine is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed (Datura), angel's trumpets (Brugmansia), and corkwood (Duboisia). Hyoscine Butylbromide is a quaternary ammonium compound and a semisynthetic derivative of scopolamine that is derived from the purified extract of the Australian native Duboisia Bush. Abdominal pain and cramps are a frequent problem in the adult population, estimated to occur in up to 30% of the population. They are considered a functional gastrointestinal tract disorder and are effectively controlled using antispasmodic agents. Hyoscine Butylbromide is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.

Hyoscine Butylbromide has high affinity for muscarinic receptors located on the smooth-muscle cells of the GI tract. Its anticholinergic action exerts a smooth-muscle relaxing/spasmolytic effect. Blockage of the muscarinic receptors in the GI tract is the basis for its use in the treatment of abdominal pain secondary to cramping.

It is used for treating spasms of the stomach, intestines or bile duct (gastro-intestinal tract), spasms associated with irritable bowel syndrome (IBS), and spasms of the bladder or urinary system (genito-urinary tract). It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place.

Hyoscine butylbromide is sometimes used to reduce secretions in the lungs. It is also effective in significantly reducing the duration of the first stage of labour and is also effective in the treatment of renal colic due to its ability to control the intense colicky pain associated with this condition. Furthermore, it is considered useful in some invasive diagnostic procedures performed on the gastrointestinal tract, such as colonoscopy and sigmoidoscopy.

The product addresses broad spectrum physiological concerns and has the band width and capabilities to meet expectations. Regular use should exhibit demonstrable results to inhibit various health related issues.

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