Ruscogenin

Alchem International with 75 years of experience in the phytochemical space has been diligently providing plant derived ingredients, active pharmaceutical ingredients and bulk drugs to all international significant geographies.

The success of the company’s operations lie in its proprietary manufacturing processes, intensive research, willingness to combat new challenges, mesh with evolving technologies, focussed expansion and credible response  to international validations and inspections.

The production sites are US FDA approved and WHO and EU GMP certified. The company has filed ASMF/DMFs in over 20 countries worldwide. Value additions through bio-technology, semi-synthesis and foot prints in the formulation space have happened in planned progression. Alchem’s interest in skin care is a logical part of this dimensional growth.

Sheer Quality drives Alchem’s operations

Through perfect blend of science and nature, dedicated research, selection of finest botanical herbal extracts and focused technology, Alchem has successfully extracted the potent active molecules in the plant and offers it for pharmaceutical use to help various companies spread wellness.

Ruscogenin
"For pharmaceutical use, Alchem offers Vinpocetine with all its inherent benefits"

Ruscogenin is a steroidal glycoside that is extracted from ruscus aculeatus (Butcher’s Broom). Ruscus aculeatus is a member of the Liliaceae family and is native to Mediterranean Europe and Africa. A variety of compounds have been isolated from ruscus aculeatus. The two primary saponin compounds are ruscogenin and neoruscogenin. The plant also contains numerous furanostanol and spirostanol saponins. In addition, a variety of flavonoids, a fatty acid mixture composed primarily of tetracosanoic acid and related compounds, chrysophanic acid, sitosterol, campesterol and stigmasterol, have been isolated from the roots.

Ruscogenin exerts its venotonic actions through an adrenergic mechanism at two levels. On the one hand, it exerts direct agonistic effects on α-1 and α-2 post-synaptic adrenergic receptors on smooth cells of the blood-vessels walls. On the other hand, it exerts indirect effects by inducing noradrenalin release from pre-synaptic neuronal storing sites. The intensity of the later effect is temperature-dependant because heat reduces receptors’ affinity for noradrenalin, thus producing vein-dilatation and characteristic symptoms, such as tired legs.

The anti-inflammatory and anti-thrombotic activities make this phytochemical useful in the treatment of peripheral vascular diseases, varicose veins, edema, haemorrhoids, premenstrual syndrome (PMS), bronchial asthma and hypotension.

The product addresses broad spectrum physiological concerns and has the band width and capabilities to meet expectations. Regular use should exhibit demonstrable results to inhibit various health related issues.

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